2. Signaling Pathways
  3. GPCR/G Protein
  4. Adenosine Receptor
  5. Adenosine A2A receptor (A2AR) Isoform
  6. Adenosine A2A receptor (A2AR) Modulator

Adenosine A2A receptor (A2AR) Modulator

Adenosine A2A receptor (A2AR) Modulator (1):

Cat. No. Product Name Effect Purity
  • HY-170948
    A2AR modulator-1
    		Modulator
    A2AR modulator-1 (Compound 45) is a selective negative allosteric adenosine A2a receptor (A2aR) modulator with an IC50 value of 9 nM. A2AR modulator-1 reduces the affinity of endogenous adenosine for the receptor and inhibits cAMP signaling pathway activation. A2AR modulator-1 potently restores pCREB phosphorylation in CD4+ T cells, reversing immunosuppression in the tumor microenvironment, and shows potential to suppress tumor growth and metastasis in triple-negative breast cancer models.